It is not always possible to reliably estimate the adverse event frequency or establish a causal relationship to product exposure using this data. Lethargy was noted for 24 to 36 hrs after the first treatment only; one cat was unsteady at 48 hrs. The formulation and dosage schedule are designed to provide a minimum of 4.5 mg/lb (10.0 mg/kg) imidacloprid and 0.45 mg/lb (1.0 mg/kg) moxidectin based on body weight. It rapidly kills 100% adult fleas within a short period of 12 hours. Advantage Multi for Cats may be administered year-around or at a minimum should start one month before the first expected exposure to mosquitoes and should continue at monthly intervals until one month after the last exposure to mosquitoes. Advantage Multi for Cats controls heartworms, fleas and gastrointestinal worms like hookworms and roundworms. In households with multiple pets, keep animals separated to prevent licking of the application site. There was a post-treatment loss of body weight in treated kittens compared to control kittens. Monthly use of Advantage Multi for Cats will control any subsequent ear mite infestations. Advantage Multi® for Cats(10% imidacloprid + 1% moxidectin) is a colorless to yellow ready-to-use solution packaged in single-dose applicator tubes for topical treatment of cats. One random-sourced cat exhibited signs consistent with either moxidectin toxicity or viral respiratory disease and died 26 hours after product application; necropsy findings were inconclusive as to the cause of death. Login . Do not dispense dose applicator tubes without complete safety and administration information. 90 product ratings - Advantage II Flea Treatment for Small Cats 5 lbs to 9 lbs - 4 Doses **READ** $33.00 Trending at $34.92 Trending price is based on prices over last 90 days. Advantage is a spot-on solution that is easy to apply and kills fleas on contact, so fleas donât have to bite to die. Updated: 2020-12-31. One owner reported a tingling sensation of the lips after kissing the treatment site. Advantage Multi ® for Cats is applied to the pet's skin. (imidacloprid + moxidectin) Topical Solution. The effectiveness of Advantage Multi for Cats in ferrets weighing over 4.4 lbs. Post-Approval Experience: The following adverse events are based on postapproval adverse drug experience reporting. During another field study, a 16-year-old cat with renal disease slept in the same place without moving for two days following application. Advantage is a once a month topical flea treatment for cats and kittens over 8 weeks or older and dogs and puppies 7 weeks or older. The following adverse events in cats are listed in decreasing order of reporting frequency: hypersalivation, depression/lethargy, application site reactions (alopecia, pruritus, lesions, and erythema), decreased appetite, vomiting, hyperactivity, ataxia, trembling, and behavior disorder (hiding). Learn more about this monthly treatment. Tremors developed in one kitten within 1 hour, resolving without treatment within the next hour. One owner reported a headache caused by chemical odor of the product. Pulmonary inflammation (1-5X) and lymphoid hyperplasia (2-1X, 4-3X) were seen in treated kittens. Advantage Multi Cats A waterproof solution, Advocate controls parasitic re-infestations by remaining active for a month. A second cat that became ill 3 days after application of Advantage Multi for Cats responded to treatment for respiratory infection and completed the study. 95. Lift tube away from skin before releasing pressure on tube. In humans, ocular and dermal irritation, nausea, numbness or tingling of the mouth and lips, anaphylaxis, pruritus, vomiting, and tongue/taste abnormalities have been reported following exposure to this product. This is temporary and does not affect the safety and effectiveness of the product. At 243-245 days post-infection, immunoserology and echocardiography were performed to identify cats with adult heartworm burdens similar to naturally-acquired infections. Search. Baytril® Otic is a topical emulsion for the treatment of canine otitis externa through the use of enrofloxacin and silver sulfadiazine. Advantage Multi for Cats should be applied between the shoulder blades. Intestinal Nematode Treatment: For the treatment and control of intestinal hookworm infections caused by Ancylostoma tubaeforme (adults, immature adults and fourth stage larvae) and roundworm infections caused by Toxocara cati (adults and fourth stage larvae), Advantage Multi for Cats should be administered once as a single topical dose. Dose Tolerance Study: Eight healthy juvenile cats were topically dosed with a single application of Advantage Multi for Cats at 10 times the recommended dose volume. Learn how advantus®, an FDA-approved soft chew, uses imidacloprid to start killing fleas within 1 hour. As specified in the following table, administer the entire contents of the Advantage Multi® for Cats tube that correctly corresponds with the body weight of the cat. This proportion difference is noteworthy because when Advantage multi for dogs with a higher percentage of moxidectin is given to felines, it can cause severe poisoning in them. Two groups were treated topically with either Advantage Multi for Cats at the label dose or placebo, once every 28 days, for three consecutive treatments. Your Basket 0 lines - £0.00. The chemical name of imidacloprid is 1-[(6-Chloro-3-pyridinyl)methyl]-N-nitro-2-imidazolidini⦠Within 4 hours, it was normal, but was found dead on day 6. Field safety Study in Ferrets: Advantage Multi for Cats was topically administered to 131 client-owned ferrets at the recommended dose volume (0.4 mL). Cats treated with imidacloprid, including those with pre-existing flea allergy dermatitis have shown clinical improvement as a direct result of elimination of fleas from the cat. Advantage Multi for cats must be administered monthly, preferably on the same date each month. Advantage for kittens is available in packs of four, and Advantage for small and large cats is available in packs of four or six. Advantage Multi for Cats is indicated for the prevention of heartworm disease caused by Dirofilaria immitis. The active ingredient, imidacloprid, spreads over your cat's body to kill fleas through contact so they do not have to bite your cat to die. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021) and others. Advantage Multi for Cats is also indicated for the treatment and control of ear mite (Otodectes cynotis) infestations and the following intestinal parasites: Do not use on sick, debilitated, or underweight cats (See ADVERSE REACTIONS). Advantage Multi is protected by one or more of the following U.S. patents: 6,232,328 and 6,001,858. * Cats over 18 lbs. Hypersalivation (8 of 12 kittens) and vomiting (12 of 12 kittens) were observed immediately post-treatment. Advantage Multi for Cats is a veterinarian-recommended topical prescription medication used for flea control, heartworm prevention, sarcoptic mange treatment, and elimination of hookworms, roundworms, and whipworms in cats. Advantage flea treatment for cats is applied to your catâs skin and gets to work quickly, killing existing fleas within one day and re-infesting fleas within an hour and for up to a month. Eligible for Free Shipping. Advantage Multi for Cats is a veterinarian-recommended topical prescription medication used for flea control, heartworm prevention, sarcoptic mange treatment, and elimination of hookworms, roundworms, and whipworms in cats. Lethargy was observed in 1 kitten from the 3X group and 1 from the 5X group on the day after initial treatment; the kitten from the 3X group was also disoriented and ataxic. The following abnormal clinical signs were reported immediately following oral administration of Advantage Multi for Cats: vomiting (one ferret) and ataxia (two ferrets). Once-a-month topical solution for ferrets for the prevention of heartworm disease, kills adult fleas, and is indicated for the treatment of flea infestations. 5. Advantage Multi for Cats provides broad-spectrum parasite protection in a convenient monthly application. Stiff, matted hair or a damp, oily appearance of the hair may be observed at the application site on some ferrets. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or online at http://www.fda.gov/AnimalVeterinary/SafetyHealth. Several otherwise healthy, thin geriatric cats experienced prolonged lethargy and sleepiness after using this drug. If contact with skin or clothing occurs, take off contaminated clothing. Bayer HealthCare LLC, Animal Health Division, P.O. No adverse reactions were associated with the topical application of Advantage Multi for Cats to experimentally heartworm-infected cats. If swallowed, call poison control center or physician immediately for treatment advice. Pull the cap off the tube. This product kills 98-100% of the fleas on cats and dogs within 12 hours. To report suspected adverse events and/or obtain a copy of the SDS or for technical assistance, call Bayer Animal Heath at 1-890-422-9874. Advantage Multi For Cats & Kittens. Have person sip a glass of water if able to swallow. In some cases death has been reported. Keep out of the reach of children. Administer the entire contents of the Advantage Multi for Cats tube (0.4 mL). Learn how ChlorhexiDerm® 4% Shampoo for pets includes chlorhexidine gluconate with penetrating agents and emollients, formulated for stability. Regulations for product use are established by country. The following abnormal clinical signs were reported during the study: wet, matted, and/or greasy appearance to the hair, shaking of the head and/or body, rubbing of dose site on cage, and shedding. One kitten in the 8.7X group apparently ingested an unknown amount of the drug and developed the following clinical signs prior to euthanasia: mydriasis, salivation, depression, vomiting, unsteadiness, rapid to slow to difficult breathing, poor pupillary response, generalized tremors, inability to move, and nystagmus. Wash skin immediately with plenty of soap and water. Advantage® II uses imidacloprid to attack the fleaâs nervous system and pyriproxyfen to prevent development of fleas. It works at various parasite life stages and can be used as an alternative to Revolution.. Advantage® II for dogs uses imidacloprid to attack the fleaâs nervous system and pyriproxyfen to prevent development of fleas. In a second study, Advantage Multi for Cats was topically applied at 0, 1.7, 5.2 and 8.7X the maximum dose to 48 healthy 9-week-old kittens every two weeks for 6 doses. Advantage Multi (Advocate) for cats is a broad-spectrum treatment that protects felines against fleas, intestinal worms, heartworms, ear mites, lice and sarcoptic mange. Advantage Multi for dogs contains 10% of imidacloprid and 2.5% of moxidectin, Advantage Multi for cats contains 10% of imidacloprid and just 1% of moxidectin. Necropsy could not determine the cause of death. Learn how Baytril® (enrofloxacin) can help treat dermal, urinary and respiratory tract infections in dogs. Immediately after dosing, it vomited, had labored breathing and slight tremors. Do not get this product in the ferret’s mouth or eyes or allow the ferret to lick the application site for 30 minutes. This product kills 98-100% of the fleas on cats and dogs within 12 hours. Avoid contact with skin. Harmful if swallowed. Advantage is a once a month topical flea treatment for cats and kittens over 8 weeks or older and dogs and puppies 7 weeks or older. All abnormalities resolved without treatment or supportive care. Do not use on sick or debilitated ferrets. Place the tip of the tube on the skin and apply the entire contents directly on the exposed skin. Flea Treatment: For the treatment of flea infestations, Advantage Multi for Cats should be administered at one-month intervals. Once-a-month topical solution for cats for the prevention of heartworm disease, kills adult fleas, is indicated for the treatment of flea infestations, as well as the treatment and control of ear mite infestations and intestinal parasite infections in cats and kittens 9 weeks of age and older and that weigh at least 2 lbs. Remove one dose applicator tube from the package. The dose of imidacloprid ranged between 21.5 and 80.2 mg/kg in this study. Children should not come in contact with the application site for 30 minutes after application. Causes eye irritation. 5. Available for Android and iOS devices. We comply with the HONcode standard for trustworthy health information -, Advantage Multi (imidacloprid + moxidectin) Topical Solution for Cats Indications, Warnings and cautions for Advantage Multi (imidacloprid + moxidectin) Topical Solution for Cats, Direction and dosage information for Advantage Multi (imidacloprid + moxidectin) Topical Solution for Cats. Do not get in eyes or on clothing. Kills adult fleas and treats flea infestations Treats ear mites with one topical dose; monthly use will control subsequent infestations Treats and controls roundworms and hookworms Sporadic vomiting and labored breathing related to heartworm burden were observed in the treatment and control groups. For a copy of the Safety Data Sheet (SDS) or to report adverse reactions call Bayer Veterinary Services at 1-800-422-9874. Part the hair on the back of the ferret’s neck at the base of the head, until the skin is visible. Wash hands thoroughly with soap and warm water after handling. Ferrets were 78 to 101 days old (11.1 to 14.4 weeks) and weighed between 1.1 to 1.8 lb (0.5 to 0.8 kg) body weight on the day of dosing, resulting in doses ranges 22.0-36.8 mg/lb (48.3-81.0 mg/kg) imidacloprid and 2.2-3.7 mg/lb (4.8-8.0 mg/kg) moxidectin. These cats were not on other medications. Advantage Multi for Cats kills adult fleas (Ctenocephalides felis) and is indicated for the treatment of flea infestations. Study in Heartworm Positive Cats: Young adult cats were inoculated subcutaneously with third-stage D. immitis larvae. 3. Three human adverse reactions were reported. Copyright © 2021 Animalytix LLC. An easy-to-give soft chew for active and aging dogs to help them maintain ongoing whole body comfort for multiple body systems. 1. Advantage Multi for Dogs prevents heartworm disease, kills fleas (Ctenocephalides felis), and treats common intestinal parasites including roundworm, hookworm, and whipworm. Part the hair on the back of the cat’s neck at the base of the head, until the skin is visible. Twist the cap to break the seal and then remove cap from the tube. Ferrets: Advantage Multi for Cats was topically applied at 5X the recommended dose volume to six healthy 9-month-old ferrets on Study Days 0, 14, 28, and 42. When replacing another heartworm preventative product in a heartworm prevention program, the first treatment with Advantage Multi for Cats should be given within one month of the last dose of the former medication. However, if youâve used Advantage II or trust it more for one reason or the other, you can always dosage it yourself. Advantage II Flea Prevention for Small Cats, 6-Dose Small Cat Flea Prevention, 5-9 Pounds In a pilot safety study using kittens younger in age and lighter in weight than allowed by product labeling, an 8-week old kitten weighing 0.6 kg orally received 2X of the label topical dose (0.46 mL/kg). Advantage Multi for Cats is a monthly, topical solution that ensures your cat is in a happy and comfortable condition! Checkout . There was no difference between treatment groups in the numbers of adult D. immitis recovered at study conclusion. WARNINGS: DO NOT ADMINISTER THIS PRODUCT ORALLY. 3.5 out of 5 stars 678. should be treated with the appropriate combination of Advantage Multi for Cats tubes. Advantage 40 Cats/Dogs/Rabbits Uu to 4kg is available online with fast delivery from VioVet, the trusted supplier of veterinary medication, foods and animal care products. Advantage Multi for Cats is indicated for the prevention of heartworm disease caused by Dirofilaria immitis. A third cat became ill on day 3 and died with signs and lesions attributable to panleukopenia on day 7 after moxidectin application. Imidacloprid is a chloronicotinyl nitroguanidine insecticide. Advantage® II uses imidacloprid to attack the fleaâs nervous system and pyriproxyfen to prevent development of fleas. While holding the tube in an upright position, remove the cap from the tube. Adverse reactions in ferrets following treatment included: pruritus/scratching, scabbing, redness, wounds and inflammation at the treatment site; lethargy; and chemical odor. Advantage® II for Cats. Histopathology showed granulomatous inflammation at the treatment site in three 1X kittens. If the cat is already infested with fleas when the first dose of Advantage Multi for Cats is administered, adult fleas on the cat will be killed. Hypersalivation was seen in one kitten from the 5X group approximately six hours post-treatment. Advantage Multi for Cats kills adult fleas (Ctenocephalides felis) and is indicated for the treatment of flea infestations on ferrets. Do not get this product in the cat’s mouth or eyes or allow the cat to lick the application site for 30 minutes. A rapid-working, monthly, spot-on treatment is an effective treatment. Adverse events reported in ferrets topically treated with 0.4 mL imidacloprid + moxidectin for cats included: malaise, vomiting, diarrhea, shaking, mydriasis, hypersalivation with abnormal neurologic signs, seizures, death, generalized hematoma of the body, and alopecia at the treatment site. ... TevraPet FirstAct Plus Flea and Tick Topical for Cats over 1.5lbs, 3 Dose Flea and Tick Prevention. The dose of moxidectin ranged between 2.2 to 8.0 mg/kg in this study. Causal relationship to the drug could not be determined. Advantage Multi ® 18 for Cats For cats weighing 9.1-18 lbs. Field Study: Following treatment with Advantage Multi for Cats or an active control, cat owners reported the following post-treatment reactions: (e.g., agitated, excessive grooming, hiding, pacing, spinning), (e.g., scratching, rubbing, head-shaking). Do not induce vomiting unless told to do so by the poison control center or physician. Advantage Multi for Cats must be given once a month. PRICE (CAD) * $12.59: Type Purple - Advantage Multi 18 - Cats Over 9 lbs, each dose: QTY. Flea Treatment: For the treatment of flea infestations on ferrets, Advantage Multi for Cats should be administered at one-month intervals. Advantage Multi® (imidaclopid + moxidectin), advantus® (imidacloprid) Soft Chews for Dogs, Baytril® (enrofloxacin and silver sulfadiazine) Otic, Baytril® (enrofloxacin) Anti-bacterial Injectable Solution, Baytril® (enrofloxacin) Antibacterial Tablets. The safety of Advantage Multi for Cats has not been established in breeding, pregnant, or lactating cats. Indicated for ferrets that weigh at least 2 lbs. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. The chemical name of imidacloprid is 1-[(6-Chloro-3-pyridinyl)methyl]-N-nitro-2-imidazolidinimine. Adverse reactions in humans included: burning, tingling, numbness, bad taste in the mouth, dizziness, and headache. Two kittens in the 5.2X group developed mydriasis, salivation, depression, squinting, and poor appetite. Advantage Multi for Cats is a monthly, topical solution that ensures your cat is in a happy and comfortable condition! Not all adverse reactions are reported to FDA CVM. Moxidectin is a semisynthetic macrocyclic lactone endectocide derived from the actinomycete Streptomycetes cyaneogriseus noncyanogenus. 100 percent effective at preventing heartworm disease caused by Dirofilaria immitis. These adverse reactions resolved without additional therapy. Advantage Multi for Cats is a broad-spectrum parasiticide that works to not only kill fleas on cats, but also eliminate ticks and ear mites. Do not use on cats less than 9 weeks of age or less than 2 lbs. Use of this product in geriatric patients with subclinical conditions has not been adequately studied. What is Advantage Multi? Advantage Multi for Cats is a medication with two active ingredients - Imidacloprid and Moxidectin. It also controls ear mite infection and demodicosis in felines. One kitten from the 3X group had a slow pupillary light response two days after treatment and one had tremors the day after treatment. All 12 kittens were either anorexic or had decreased appetite for at least 1 day following treatment. In 3 kittens, the anorexia or decreased appetite continued into the second week following treatment. It is a monthly spot-on treatment that ⦠One kitten from the 3X group was scratching at the treatment site 2 days after treatment. Remove one dose applicator tube from the package. 4. body weight. A kitten in the 1.7X group developed mydriasis. In households with multiple pets, keep animals separated to prevent licking of the application site. The poison control center or physician immediately for treatment advice, it was normal but. Within 4 hours, it vomited, had labored breathing and slight tremors noted for to. 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